Regulation of Deoxyribonucleic Acid Synthesis
نویسنده
چکیده
These enzymes (Grav, 1967) are responsible for the synthesis of the monomeric precursors of DNA, namely dATP, dCTP, dGTP and dTTP. Fluctuations in the activities of some of the enzymes and in the intracellular deoxyribonucleotide pools are known to occur throughout the cell cycle (Grav, 1967; Nordenskjold et al., 1970; Adams et al., 1971 ; Skoog & Nordenskjold, 1971). Moreover, there is induction of synthesis of several of the enzymes after infection of mammalian cells with DNA viruses (Keir, 1968). It is therefore possible that there is a closely regulated relationship between the replication of DNA and the provision of the nucleotide precursors.
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